I've read 23 of them, and I'm glad that most of them made it, although I'm not quite sure about Neal Stephenson's Snow Crash. I'm glad that William Faulkner and Graham Greene each got two novels on the list. And there's a few that I'd really like to read in the near future, among them: Joan Didion's Play it as it Lays and maybe something by Saul Bellow.
Also worth reading are the original reviews of many of these books. Some of them, such as Pynchon's The Crying of Lot 49, were at first reviled. Others were immediately recognized as masterworks. My favorite, however, is the 1966 review of The Lord of the Rings, which describes what was evidently a major Tolkien craze on college campuses:
The hobbit habit seems to be almost as catching as LSD. On many U.S. campuses, buttons declaring FRODO LIVES and GO GO GANDALF—frequently written in Elvish script—are almost as common as football letters. Tolkien fans customarily greet each other with a hobbity kind of greeting ("May the hair on your toes grow ever longer"), toss fragments of hobbit language into their ordinary talk. One favorite word is mathom, meaning something one saves but doesn't need, as in "I've just got to get rid of all these mathoms." Permanently hooked Ringworms frequently memorize long passages from the trilogy and learn how to write Tengwar or Certar, two peculiar and ancient-looking scripts that Tolkien invented on behalf of his mythical creatures. The most ardent readers of all are likely to join the nation's fast-growing Tolkien Society of America, which publishes magazines containing learned disquisitions on the elaborate genealogies and intricate rules of grammar that the author attached as appendices to the trilogy.